Metadata (abstracts and keywords) for the articles in the journal
Dol A.V., Mikhin M.N. Regression models of atherosclerotic plaque biomechanics and their statistical optimisation // Vestnik I. Yakovlev Chuvach State Pedagogical University. Series: Mechanics of a limit state . 2025. № 1(63). p. 29-39
Author(s):
Dol A.V., Mikhin M.N.
Index of UDK:
539.374
DOI:
10.37972/chgpu.2025.63.1.011
Title:
Regression models of atherosclerotic plaque biomechanics and their statistical optimisation
The paper addresses a number of issues related to the study of carotid artery stenosis. To assess the risk of plaque detachment by biomechanical methods, it is necessary to know the elastic moduli of atherosclerotic plaque components. They can be determined in vivo from the value of the Hounsfield units (HU) on a computed tomography (CT) scan. In a series of experiments (26 patients), the Young’s moduli of the specimens considered were determined by uniaxial compression of atherosclerotic plaques removed during endarterectomy, and then the average Hounsfield unit for each plaque was determined on CT. A regression relationship between Young’s modulus and Hounsfield units was constructed from the data obtained. The obtained regression relationship allows us to determine the mechanical properties of individual structural elements of plaques by CT and use them in biomechanical modelling to assess the risk of detachment and further thrombosis.
The contact details of authors:
Alexander V. Dol, PhD in Physics and Mathematics; e-mail: dolav86@yandex.ru; https://orcid.org/0000-0001-5842-1615; AuthorID: 601135
Mikhail N. Mikhin, PhD in Physics and Mathematics; e-mail: mmikhin@inbox.ru; AuthorID: 493518
Russian
English